세계 주요 우울 장애 시장 – 2023-2030

Overview
Global Major Depressive Disorder Market reached US$ YY billion in 2022 and is expected to reach US$ YY million by 2030 growing at a CAGR of YY% during the forecast period 2023-2030.
Major depressive disorder (MDD) also referred to as depression, is one of the most severe and common psychiatric disorders across the world. It is characterized by persistent sadness, loss of interest or pleasure, low energy, worse appetite and sleep, and even suicide, disrupting daily activities and psychosocial functions.
MDD is a condition characterized by mood swings, which can be triggered by various factors such as genetics, stress, hormone imbalance, alcohol or drug use, certain medical conditions, specific medications, and childhood abuse. The exact cause is unknown, but these factors can increase the risk of developing MDD.
Market Dynamics: Drivers and Restraints
Rise in technological advancements in treatment options
Over the past two decades, significant progress has been made in the treatment options for major depressive disorder (MDD). It is now recognized that depression varies from person to person, and efforts are being made to identify and diagnose the specific neurochemical imbalances in individuals to tailor treatment accordingly.
Advances have been made in evidence-based treatments, particularly in drug therapy. More selective and specialized antidepressants, such as citalopram, escitalopram, fluoxetine, and sertraline, have been developed, offering improved efficacy and fewer side effects. Combining drug therapy with psychotherapy, specifically cognitive-behavioral and psychodynamic therapy, has been shown to be the most effective approach.
For instance, Eliem Therapeutics, Inc a clinical-stage biotechnology company focused on developing novel therapies for neuronal excitability disorders to address unmet needs in chronic pain, psychiatry, epilepsy and other disorders of the peripheral and central nervous systems, provided an update on its plans to advance its ETX-155 clinical program.
Furthermore, Work life imbalances due to lifestyle changes, and an increase in the MDD patient pool are the key drivers expected to drive the MDD treatment market over the forecasted period. Partnerships for co-development and co-marketing of MDD drugs among drug manufacturers across the globe, the development of new drugs, and adequate government reimbursement policies have also fueled the growth of the MDD treatment market.
Market Dynamics: Restraint
Major depressive disorder (MDD) can cause more than depression. It can lead to complications that affect your health and change how you think and behave. Some of the complications include weight gain and obesity, chronic illness, chronic pain, self-harm, cognitive changes and others.
However, stringent regulations imposed by various governments for new drug approval, patent expiries of some blockbuster drugs, risk of complications with other medications, and related side effects of major depressive disorder drugs hamper the growth of the major depressive disorder treatment market over the forecasted period.
Segment Analysis
The global major depressive disorder is segmented based on drug type, route of administration, distribution channel and region.
The Antidepressants from the drug type segment accounted for approximately 41.2 % of the market share
The Antidepressants from the drug type segment accounted for approximately 41.2 % and it is expected to be dominated during the forecast period. Antidepressants are psychiatric drugs which are licensed to treat depression. Some are also licensed to treat other conditions, such as anxiety disorders phobias, bulimia (an eating disorder), and some physical conditions, including managing long-term pain.
For instance, in December 2022 AbbVie announced that the U.S. Food and Drug Administration (FDA) has approved VRAYLAR (cariprazine) as an adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD) in adults. Supported by clinical data demonstrating efficacy and well-established tolerability, this additional indication provides a new option for adults who have a partial response to the treatment of an antidepressant.
Moreover, in September 2022 Otsuka Pharmaceutical Co., Ltd. (Otsuka) announced positive results from a phase III clinical trial in Japan of brexpiprazole in the treatment of major depressive disorder. The late-stage trial evaluated the efficacy and safety of brexpiprazole as adjunctive therapy in 740 adult patients in Japan, aged 20 to 64 years, with major depressive disorder. Brexpiprazole was administered once daily for six weeks, in 1 mg or 2 mg doses, as an adjunctive therapy to SSRI or SNRI antidepressants, for patients who previously had inadequate responses to antidepressant monotherapy.
Geographical Analysis
North America accounted for approximately 38.4% of the market share in 2022
North America is estimated to hold about 38.4 % of the total market share throughout the forecast period, owing to an increase in the number of patients suffering from major depressive disorder, advancement in technology to develop new therapeutic drugs, rise in the ongoing clinical trials, advanced healthcare infrastructure and among others are expected to dominate by this region during the forecast period.
For instance, according to clinicaltrails.gov in September 2022 Janssen Research & Development, LLC started clinical studies on a Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD) (VENTURA-LT) which is under phase 3 with 840 active participants have been enrolled and these studies have been going in Alabama United states.
Moreover, according to clinicaltrails.gov on November 2022 Otsuka Pharmaceutical Development & Commercialization, Inc started a clinical study on a Trial of the Safety and Efficacy of SEP-363856 in the Treatment of Adults With Major Depressive Disorder which is under Phase 3 with 900 enrolled participants and this studies currently going in New York United States.
COVID-19 Impact Analysis
COVID-19 had a substantial impact on major depressive disorder where according to studies published on the Impact of the COVID-19 pandemic on major depressive disorder in acute psychiatric inpatients where the studies focused on the relationship between COVID-19 and mental disorders reported results similar to those summarized above about psychiatric symptoms in the general population.
In particular, a large systematic review and meta-analysis found an increase of 27.6% in the prevalence of major depressive disorder (MDD) after the outbreak of the COVID-19 pandemic (COVID-19 Mental Disorders Collaborators, 2021) with a peak of the incidence from March to May 2020 in conjunction with the first restriction measures.
Market Segmentation
By Drug Type
• Antidepressants
o Selective Serotonin Reuptake Inhibitors (SSRIs)
o Dopamine Norepinephrine Reuptake Inhibitor
o Serotonin Norepinephrine Reuptake Inhibitor
o Serotonin Modulators
o Monoamine oxidase inhibitors (MAOIs)
o Others
• Atypical Antidepressants
• Antipsychotics
• Neuromodulators
By Route of Administration
• Oral
• Intravenous
• Parenteral
By Distribution Channel
• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies
By Region
• North America
o U.S.
o Canada
o Mexico
• Europe
o Germany
o U.K.
o France
o Spain
o Italy
o Rest of Europe
• South America
o Brazil
o Argentina
o Rest of South America
• Asia-Pacific
o China
o India
o Japan
o Australia
o Rest of Asia-Pacific
• Middle East and Africa
Competitive Landscape
The major global players in the major depressive disorder market include Eli Lilly and Company, Allergan, Alkermes, Lundbeck, Johnson & Johnson, Pfizer, Inc, AstraZeneca plc, Merck & Co, GlaxoSmithKline plc, Sanofi S.A and among others.
Key Developments
 In September 2023 Relmada Therapeutics, Inc., a late-stage biotechnology company addressing diseases of the central nervous system (CNS), announced efficacy results for the de novo (or new to treatment) patients (204 patients) and safety results for all subjects (627 patients) from the Phase 3, long-term, open-label, registrational trial (Study 310) of REL-1017 in patients with Major Depressive Disorder (MDD).
 In August 2023 Biogen Inc. and Sage Therapeutics, Inc announced the U.S. Food and Drug Administration (FDA) approved ZURZUVAE (zuranolone) 50 mg for adults with postpartum depression (PPD). ZURZUVAE is the first and only oral, once-daily, 14-day treatment that can provide rapid improvements in depressive symptoms for women with PPD.
 In May 2023 - BioXcel Therapeutics, Inc., a biopharmaceutical company utilizing artificial intelligence approaches to develop transformative medicines in neuroscience and immuno-oncology, announced positive top-line data from its Phase 1b multiple ascending dose (MAD) trial of BXCL501 (dexmedetomidine) sublingual film.
Why Purchase the Report?
• To visualize the global major depressive disorder market segmentation based on drug type, route of administration, distribution channel and region as well as understand key commercial assets and players.
• Identify commercial opportunities by analyzing trends and co-development
• Excel data sheet with numerous major depressive disorder market-level data points with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as excel consisting of key products of all the major players.
The global major depressive disorder market report would provide approximately 69 tables, 70 figures, and 185 Pages.
Target Audience 2023
• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies